From Pittsburgh to the Poconos, communities are being warned about possibly heavy mixed precipitation, with possible snow totals ranging from a dusting to 15 inches.
Gov. Tom Wolf on Friday declared state of emergency ahead of the storm.
The state will impose speed restrictions and a ban on all commercial traffic on interstates and the Pennsylvania Turnpike. Residents are urged to avoid travel if possible.
The storm should sweep into Pennsylvania on Saturday morning, tracking its way across the state by afternoon.
The National Weather Service says Pittsburgh could get as much as 11 inches, parts of the Poconos could get 15 inches and Philadelphia’s suburbs could get 8 inches.